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further identified seven tear fluid proteins with significantly altered expression, that had a role in protein repair and clearance system or regulation of the cytoskeleton 20

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5-Amino-1MQ, as an NNMT inhibitor, alters a pathway involved in NAD+ and methylation balance, and its long-term effects in people are simply unstudied

Moreover, from known examples, they are quite variable among GST classes which likely explain the diversity of substrates accommodated by the different GSTs but may at the same time also explain the lack of specificity among certain classes for some substrates (Wilce and Parker, 1994