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Increasing systemic levels of L-Arginine has been demonstrated to significantly improve endothelial function in individuals with essential hypertension, compromised flow-mediated dilation, arterial stiffness, chronic heart failure, impaired glucose tolerance, and type 2 diabetes-all of which are common concomitant medical conditions associated with Erectile Dysfunction (ED).

Medscape Drugs & Diseases

A study by Pickart et al

Retrograde Mitochondrial-Nuclear Signaling One interesting feature of MOTS-c biology is that MOTS-c seems to travel to the nucleus of cells under conditions of stress and alter the expression of nuclear genes that control antioxidant defences as well as metabolic programs