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Refolo MG, Lippolis C, Carella N, Cavallini A, Messa C, DAlessandro R

Methods of altering antibodies to target (e.g., inhibit) intracellular portions are well known in the art, e.g., using single chain antibodies (scFv), modifying immunoglobulin VL domains to achieve hyperstability, modifying antibodies against reducing intracellular environments, generating fusion proteins that increase intracellular stability and/or modulate intracellular localization, and the like