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5.3.3 CRISPR/dCas9-VPR activates the SCN1A promoter, enhancing neuron-specific Nav1.1 expression The CRISPR/dCas9-VPR system utilizes guide RNA-directed targeting of catalytically dead Cas9 (dCas9) fused to the transcriptional activator VPR to specifically upregulate endogenous SCN1A expression from its native promoter

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Increased energy expenditure in females: supplemented female Labrador Retrievers demonstrated significantly higher maximum and mean energy expenditure during treadmill exercise compared to females receiving the placebo