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Ethics statement The studies involving humans were approved by the National Center for Health Statistics Institutional Review Board ( The studies were conducted in accordance with the local legislation and institutional requirements

Basis size ( k x ) for the neonicotinoid smooth term ( k 1 ) was set to four, and for the DEM smooth term ( k 2 ), it was set to three, i.e., the maximum size for this experimental design

However, Barry and El Eini (30) studying the solubilization of non-polar steroidal drugs in aqueous solutions of long-chain polyoxyethylene nonionic surfactants have observed that the molar solubilizing efficiency of surfactants increased as the length of the PEO chain increased while micellar sizes are known to decrease with the increase in PEO chain length