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Moreover, glutamine-induced activation of mTORC1 results in the phosphorylation of the enzyme complex called carbamoyl phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD), which catalyzes the condensation reaction converting glutamine-derived nitrogen into the pyrimidine precursor orotate 34,35

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[7] When infused in high millimolar concentrations together with arginine, lysine saturates cationic amino-acid transporters on proximal-tubule apical membranes, limiting re-absorption of radio-peptides such as ^177Lu-DOTATATE