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The vial math below assumes a 5 mg vial reconstituted with 2.0 mL BAC water (2.5 mg/mL) for the 2.4 mg/week target

Katt et al., Validation of BBB Models for Epilepsies Vascular damage is a key factor in epileptogenesis since it permits extravasation of peripheral immune cells from the circulation which augment inflammatory responses and increase neuronal excitability (Lscher, 2020)