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Pregnancy: There are no data from the use of pemetrexed in pregnant women but pemetrexed, like other antimetabolites, is suspected to cause serious birth defects when administered during pregnancy,so should not be used during pregnancy unless clearly necessary, after a careful consideration of the needs of the mother and the risk for the foetus

Daily high doses of B12 may not likely cause harm in most people, but extremely high doses should possibly be avoided unless a healthcare professional prescribes it

Clients might have allergic reactions or rare injection site infections

doi: 10.1016/j.jneuroim.2005.10.005 12