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The livers main function is to detoxify the body and process nutrients, but this comes with a costoxidative stress

Similarly, conditions like celiac disease damage the intestinal lining, impairing nutrient absorption

In fact, a prior study demonstrated that children residing in konzo-prone regions of the DRC had a collective micronutrient deficiency that trended with disease severity, but such deficiencies are commonplace in populations across sub-Saharan Africa including those with low incidence of konzo 18

Indeed, patients with renal failure may have relative erythropoietin deficiency, i.e., normal erythropoietin levels that are actually too low in view of the degree of anemia