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A decrease in mtDNA-CN is often observed not only in aging but also in neurodegenerative diseases, such as Alzheimer's disease (AD) and PD, where mitochondrial dysfunction contributes to the disease pathology (Lin and Beal 2006)

(2) more efficient and feasible strategies for regulating properties of CLgens since the performance of most CLgens still lags behind that of traditionally conjugated luminescent materials 62

By replacing the glutamic acid at position 3 with an arginine and adding a 13 amino acid extension at the N-terminus, this peptide exhibits a significantly decreased affinity for insulin-like growth factor-binding proteins

doi: 10.1016/j.jep.2022.115021 170 LiMMengZYuSLiJWangYYangWet al