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Abstract We investigated the longstanding idea that the onset of psychotic symptoms in schizophrenia arises from an early phase of glutamate neurotoxicity, possibly related to loss of GABA restraint, oxidative stress or inflammation, that cumulatively results in a later phase of synaptic loss in keeping with magnetic resonance spectroscopy (MRS) evidence of reduced glutamate in schizophrenia, especially in older patients

A significant increase in glucose uptake was observed in the distal intestine of metformin-treated mice compared with that in vehicle-treated mice (Fig

J Allergy Clin Immunol (2015).10.1016/j.jaci.2015.01.042 36 SandigHBulfone-PausS

Even though that phase doesn't occur, the symptoms are the same