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We used our model for APAP metabolism, integrated with our model for GSH metabolism[9] to compute the concentration of hepatic GSH and the amount of covalent binding of NAPQI after various doses of APAP

This ability to support an anabolic state makes MK-677 a potential therapeutic tool for managing catabolic conditions, enhancing muscle retention and recovery under restricted diets or high physical stress

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A forward chemical genetic screen reveals gut microbiota metabolites that modulate host physiology