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In mouse models, reduction of Aldh3a2 induced ferroptosis in leukemic cells and was synergistically lethal combined with the inhibitor of glutathione peroxidase 4 (GPX4) RSL3, whereas it was dispensable for normal hematopoiesis

It is synthesized from 10-deacetyl baccatin III into a single diastereomer which is found in many Taxus species

International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 8:32-45, 2019