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The same group performed another study [253] to investigate whether the consumption of juice rich in flavanone (500 mL of orange juice) is associated with acute cognitive benefits and changes in the cerebral circulation in young subjects (between 18 and 30 years old) undergoing cognitive tests

When local expression of IGF-1 was blocked by the binding of Wnt induced secreted protein 3 (WISP3), a protein involved in cell differentiation, IGF-1-induced collagen X expression was also reduced [211]

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