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The brain must generate large amounts of ATP to maintain the membrane potential, which is essential for the transmission of nerve impulses

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Activation of Ret triggers two key signaling pathways: the PI3K/Akt pathway directly inhibits the mitochondrial translocation of the pro-apoptotic protein Bax, and the MAPK/ERK pathway enhances mitochondrial biogenesis by upregulating peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1), and the Src kinase pathway is involved in regulating the survival and axonal regeneration of dopaminergic neurons [70]