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Kla suppresses NK cell function by creating cold TMEs, with high Kla scores correlating negatively with TME stromal/immune/estimation scores and positively with tumor purity, indicating promotion of immune desert-type TMEs where reduced NK cell infiltration weakens tumor immune surveillance (118)

Additionally, the stimulated release of mitochondrial cytochrome c (cyt c) into the cytoplasm induces apoptotic cell death [25,26]

A clinical trial shows improvement in skin collagen, hydration, elasticity, wrinkles, scalp, and hair condition following 12-week oral intake of a supplement containing hydrolysed collagen

However, challenges remain in the clinical translation of this cell therapy