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some PFIC types have been described as at risk of liver cancer development

For example, simultaneously evaluating the expression, enzyme activity, and lipidomic characteristics of GPX4, SLC7A11, ACSL4, LPCAT3, FSP1, and DHODH in the same batch of patient tissues, combined with disease staging and tissue-specific differences between cartilage and synovium, can clarify the dominance of each pathway at different stages