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Recent studies have reported potential therapeutic targets for CIPN including endogenous lipid-related molecules (such as SPMs), and the use of stem cells

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Yuan X, Yuan W, Ding L, Shi M, Luo L, Wan Y, Oh J, Zhou Y, Bian L, Deng DYB (2021) Cell-adaptable dynamic hydrogel reinforced with stem cells improves the functional repair of spinal cord injury by alleviating neuroinflammation

As I mentioned in Article Breakdown Mechanisms of Pathogenesis in Drug Hepatotoxicity Putting the Stress on Mitochondria, I believe that this paragraph describes much of what occurs in floxed cells: Increased steady-state levels of mitochondrial superoxide, arising from reduction of Sod2 activity in the Sod+/mice (i.e., approximately half the wild-type activity), may be exacerbated by drugs that directly target the ETC [e.g., the complex I inhibitors flutamide and troglitazone (122)]