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After he had received the combination of all therapies (TPE, UCT-MSC-EXs, Epitalon, and Semax), the patients CNS-VS testing, performed in December 2023 (18 months after baseline testing), showed significant improvement in composite memory, verbal memory, reaction time, and psychomotor speed, going from 2/12 in the average category at baseline to 7/12 in the average category (Table 4)

10.1016/j.tranon.2023.101817 123 XuS.WuB.ZhongB.LinL.DingY.JinX.et al (2021b)

The incentive to make a definitive histologic diagnosis, however, is partly dependent on the possible risks of a biopsy, as well as the risks involved with particular treatments

Additionally, to improve transparency, the study design and experiments were reported following ARRIVE 2.0 (Animal Research: Reporting of In Vivo Experiments, 2020) guidelines and the 3R/6R principles