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Phase I reactions are usually the initial steps in the biotransformation process, generating metabolites that can serve as substrates for Phase II conjugation reactions

Unsurprisingly, enzymes containing FeS clusters are particularly susceptible to iron deficiency and oxidative stress [76,77], as the instability and gradual degradation of these clusters can cause irreversible damage to the enzyme's protein backbone [78]

It has also been surprisingly found, as noted previously, that adding at least one amino acid to an aqueous solution of at least one peptide copper complex (as disclosed above), enhances the ability of the at least one peptide copper complex to remain solubilized

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