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The parenteral administration also halts the progression of neurological damage associated with B12 deficiency, but the complete improvement of the condition may depend on the severity and extent of the deficiency.[12][13] Contraindications & Precautions Cyanocobalamin is contraindicated in those with hypersensitivity to cobalt moiety or cobalamin molecule due to the risk of anaphylaxis.[21] Warnings: The use of cyanocobalamin is warned in patients with early Lebers disease as there have been reports of severe and swift optic atrophy with its administration

Journal of Physiology-Paris , 93 (6), 479485

This positive charge interacts with the acidic environment of the stomach, effectively creating a local buffer zone around the peptide

Clinical trials showed an average loss of 6 pounds over 12 weeks compared to 2 pounds with placebo