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In addition, TST has also been reported to sensitize tumour cells to chemotherapy drugs, such as 5-FU and oxaliplatin, and increase their efficacy [25]

Indeed, a 2019 literature review discussed berberines potential for antitumor effects against a few types of cancer, and a more recent review from 2024 highlighted its ability to support chemotherapy.13 49 At this time, the most extensive research on berberine has revolved around its impacts not on cancer but on diabetes and cholesterol management, so those are the health concerns for which the supplement is most likely to yield benefits

Ma M-W, He K-L, Li C-Q, Xie X-T, Zhou S, Zhang B, et al

A decreased relative spleen weight was observed at 187 and 425 mg/m 3 in both sexes