glutathione peroxidase function The family: Discoveries and mechanism Glutathione peroxidase 1 - Wikipedia

For example, cellular senescence, classified as an antagonistic/secondary hallmark of aging, results as a consequence of persistent DNA and/or proteomic damage (primary hallmarks) that drives integrative hallmarks such as chronic inflammation and altered intracellular signaling, which further perpetuate other aging hallmarks

[PMC free article: PMC5498918] [PubMed: 28624262] 266

In: Elsner P, Maibach H, editors

On testing cadence, note that there is no universal evidence-based schedule: the frequency of laboratory monitoring should be individualized according to the therapy being used, underlying medical conditions, treatment response, and current clinical guidelines