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Cell 133 , 704715 (2008)

[342] Prominent large clinical trials in eye health, primarily focused on AMD, include the Age-Related Eye Disease Study (AREDS) and its subsequent study, AREDS2 [343] , as well as the Nutritional AMD Treatment 2 (NAT2) [344] , and National Eye Institute (NEI)-supported AMD studies [345] , collectively enhancing our knowledge of the influence of supplements, nutrients, vitamins, and minerals, notably in the context of AMD

A study has reported that mtDNA damage in peripheral blood mononuclear cells is significantly higher in patients with ARCs compared to healthy controls [97]