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2.5 Hepatocellular carcinoma metabolic heterogeneity and its diagnostic value The existence of intra-tumor heterogeneity (ITH) has been firmly established in numerous cancers, encompassing temporal, spatial, and TME (metabolic and immunological components) heterogeneity, and further exerting influences on the heterogeneous behavior of tumor cells and alterations in the immune cell immune response (81)

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In the preclinical studies, exogenous oxytocin administration proved to be a promising therapeutic approach, effectively enhancing social behaviors while reducing repetitive behaviors in rats prenatally exposed to VPA [31, 41] and BALB/cByJ mice [39]