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Male rats receiving this exposure showed only a slightly increased liver weight

Blanco et al

There are numerous lines of evidence that exogenous spermidine can be applied to enhance the growth, raise endogenous polyamine levels, eliminate ROS, safeguard the activity of the antioxidant enzyme system, and preserve the integrity of plant cell function 58,59

However, due to the insufficient number of tumor-specific effector T cells in the patient's body and the inhibitory effect of the tumor immune suppressive microenvironment on immune cells, not all patients respond to immunotherapy