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The patients blood pressure declines within 30 to 60 minutes after an oral dose, the maximum decrease occurring within 2 to 4 hours

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Rapid reduction or abrupt discontinuation of opioid analgesics in patients who are physically dependent on opioids has resulted in serious withdrawal symptoms, uncontrolled pain, and suicide

In the lipid-rich environment of the CNS, ferroptosis could therefore play a significant role in secondary damage, the neuron-astrocyte interaction is also critical for maintaining brain lipid metabolism, indicating that neurons may be more sensitive to drastic changes in lipid peroxidation, moreover, lipid peroxidation contributes to secondary damage after SCI and highlights the possible use of lipid metabolism regulator to treat SCI [46,47,48]