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E-cadherin, a cell adhesion molecule, is upregulated, disrupting tissue integrity and is influenced by the Wnt/-catenin signaling pathway, which affects cell-cell interactions and tissue cohesion

Of potential relevance, it has been shown that tricyclic antidepressants like amytriptiline, sensitized against APAP hepatoxicity by inhibiting acidic sphingomyelinase (ASMase), which resulted in lysosomal cholesterol accumulation

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In a teratology study of acetylcysteine in the rabbit, oral doses of 500 mg/kg/day (2.6 times the human mucolytic dose) were administered to pregnant does by intubation on days 6 through 16 of gestation