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EMA also determined that more than one-third of products (34.9%) did not meet the orphan drug designation threshold for significant benefit over existing treatments for hematological malignancies and non-oncological hematological diseases

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References Vasireddi N, Hahamyan H, Salata MJ, et al

Instead of treating BPC-157 as acting in one isolated tissue, NO pathway research helps explain why the compound is discussed across multiple experimental systems