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Melatonin has also been implicated in the suppression of autophagy under various stress conditions, including nicotine exposure, serum starvation, excessive autophagy, and unpredictable stress, possibly through modulation of miR-15a-5p, PI3K/Akt/mTOR, and eIF2/ATF4 pathways (Wang et al., 2018

Intriguingly, ibuprofen users showed a lower risk for PD, whereas no protective effect could be demonstrated for acetylsalicylic acid (ASA) (114)

BELN supplementation also improves liver dysfunction and insulin resistance in NAFLD, which is accompanied by a reduction in AST and ALT levels and fat deposition as well as a downregulation in acetyl-CoA carboxylase 1 (ACC1) and fatty acid synthase (FAS) expression (252)

By controlling the production of pyocyanin and strictly regulating its use, its advantageous properties can be harnessed while limiting its adverse effects