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Refrigeration slows oxidation but doesn't stop it

Bitterman KJ, Anderson RM, Cohen HY, Latorre-esteves M, Sinclair DA (2002) Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1

If results remain unexplained, particularly with very high levels, further investigation may include imaging or haematology referral depending on clinical context and associated abnormalities