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41, 42 The impact of IC/BPS on QoL is as severe as that of rheumatoid arthritis and end- stage renal disease

Depression and pain comorbidity: a literature review

Then, we performed validation experiments via qRT-PCR for four hub genes ( Vwf , Vegfa , Kdr , Spp1 ) closely related to the PI3K/AKT signaling pathway, and the results aligned with the RNA-seq data