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Additionally, we found that melatonin continued to have suppressive effects on ILC2 effector function even in the presence of MT1 and MT2 antagonists ( Figures 3BE )

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Hormonal treatment given to animals or individuals with established cardiovascular disease may initiate a different set of physiological responses compared to responses in the absence of established disease

Studies have demonstrated that ALOX15 exacerbates I/R-induced brain injury [305] and ischemia-induced myocardial injury [306] by inducing PL-PUFA peroxidation and ferroptosis, suggesting the therapeutic potential of targeting ALOX15 for these I/R-induced tissue injuries