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Biochem Biophys Res Commun 327:866870

Khn, T

The activation of inflammation by leukocytes and phagocytic cells can trigger an intrinsic production of reactive oxygen species to cause unwanted DNA damage and activation of nuclear factor-kappaB (NF-B), central players in cancer development, offering a potential mechanism of PDAC development through T2D-linked inflammation, although not exclusive to T2D ( Figure 3 ) (64, 86)