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Overexpression of in transgenic rice yielded significant increase of the zinc content in grain by 40-50% compared to wild type, making first step of possibility to fight zinc deficiency with zinc-rich rice (Yang et al., 2009)

In addition, in a rat renal ischemiareperfusion injury model, bardoxolone methyl decreased urea, creatinine, NGAL, total oxidant status, nitric oxide, and ADMA levels, increased SOD and GSH-Px activities, and upregulated renal Nrf2 and PPAR expression, suggesting that its anti-oxidative, anti-inflammatory, and anti-apoptotic effects collectively mitigate AKI severity (258)

doi: 10.1097/CM9.0000000000001214 59 TersigniCVatishMD'IppolitoSScambiaGDi SimoneN