ipamorelin human study growth hormone secretion clinical trial

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P362 Chang D

JD: Conceptualization, Supervision, Validation, Writing original draft, Writing review & editing

Studies on sepsis mouse models have shown that up-regulation of PD-L1 can inhibit the activity of caspase-3 and up-regulate the expression of Mcl-1 through the PD-1/PI3K/Akt signaling pathway, thereby delaying neutrophil apoptosis, leading to their abnormal accumulation in the lungs and exacerbating lung injury (42)