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Key benefits for perimenopausal women: Supports faster repair of tendons, ligaments, and muscle tissue that become more injury-prone as estrogen falls Reduces local inflammation through macrophage M1-to-M2 polarization, which may ease joint pain and soft-tissue discomfort common in perimenopause Promotes angiogenesis via endothelial cell migration and tube formation, improving blood supply to areas of chronic or recurring injury Administration method: Subcutaneous injection, typically into the abdomen with rotating injection sites

SOD2 or MnSOD: 5-GGGAGTTGCTGGAAGCCAT-3 (nucleotides 381399 for both human, NM_000636, and rat, NM_017051)

Steviosides also alleviate cardiac fibrosis by inhibiting the TGF-/Smad pathway and regulating the protein expression of MMP2/9 and TIMP2/4

Current studies on myofascial pain syndrome