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Kligman AM, Willis I

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Close inspection of our SNIP1-P-SF3B1 interaction model also indicates that E366 is in close proximity to the binding interface and its mutation to glycine (E366G) induces most likely local conformational changes in the FHA domain leading to suboptimal P-SF3B1 binding (Fig

Maybe its due to the proximity to the sea (15 minutes) or possibly to an odd commingling of riversone sweet, one saltybehind the shops and cafs leaning into one another along Water Street