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BCR-ABL encodes a constitutively active tyrosine kinase that phosphorylates a panel of downstream targets to cause uncontrolled cell proliferation, protein synthesis, and anti-apoptotic signals 3,4,5,6

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The enzyme uses either iron or manganese as a cofactor and catalyzes the degradation or reduction of hydrogen peroxide (H 2 O 2 ) to water and molecular oxygen, consequently completing the detoxification process imitated by SOD