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[4] The term "onion-skin" is sometimes used to describe this form of blood vessel [14] with thickened concentric smooth muscle cell layer and thickened, duplicated basement membrane

This causes dissipation of the internal membrane potential and generation of ROS, followed by rupture of the external membrane and non-specific release of intermembrane space proteins into the cytosol, which activate various signal transduction pathways such as apoptosis (84)

Antibody binding was detected with the Odyssey Imaging System (LI-COR, Lincoln, NE, USA)

ACR is produced by both cellular biochemical processes and oxidative reactions outside of the body