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(2004) J.Recept.Signal.Transduct.Res

Furthermore, inhibiting TLR4 can also modulate gut microbiota homeostasis and the MyD88/NF-B axis in ulcerative colitis (164), indicating that TLR4 acts not only as a key sensor of innate immunity but may also regulate neuroimmune crosstalk and gut microenvironment homeostasis

258 An effective delivery vehicle should provide efficient entry into the cell, protection of nucleic acid against degradation by nucleases, and release of the nucleic acid in functional form in the nucleus