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In summary, subgroup analyses revealed that patients with GFR below 90 ml/min/1.73 m 2 , selenium below 70 g/l and GPx3 activity below 250 U/l at baseline were likely to respond to selenium supplementation with an increase in GPx3 activity, which may be a prerequisite for clinical improvement

More studies are warranted to confirm its long-term efficacy and preventive role against malignant transformation of digestive precancerous lesions as evidence is insufficient