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The underlying mechanism involves copper ions interfering with the levels of Fe-S cluster proteins by directly binding to the lipoylated components of the citric acid cycle (CAC) in mitochondrial respiration

However, many of these studies involved co-supplementation with other nutrients such as magnesium, calcium, and vitamin D, making it difficult to isolate the specific effects of zinc alone

Larry Lands, a cystic fibrosis researcher at Montreal Children's Hospital, explored the isolate's effects on muscle performance

More importantly, oral administration of these compounds leads to their accumulation in the brain, heart, muscle and liver mitochondria (Ross et al., 2005)