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Description

10.1038/s41598-019-43882-4 14

6.3 pH In the avascular environment of the intervertebral disc (IVD), energy metabolism primarily relies on glycolysis, producing large amounts of lactic acid, placing the healthy nucleus pulposus (NP) in an acidic environment (pH 7.07.2)

TDP-43 TDP-43 has a multiple-domain structure consisting of an NTD that mediates weak self-interactions 72,73 , two RRMs, an intrinsically disordered CTD that mediates heterotypic interactions with binding partners using glycine-rich LCD, and helix-helix contacts for self-assembly by LLPS 74,75