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Marks points out that at that time the two hormones produced by pancreatic islet A and B cells were regarded as 'biological antagonists rather than subtle collaborators in blood glucose control' (Marks 2018)

lowest tolerated dose Phase Step 2 Weeks Weeks 5-8 Cagrilintide Dose 0.5 mg/week Purpose Dose escalation Phase Step 3 Weeks Weeks 9-12 Cagrilintide Dose 1.0 mg/week Purpose GI side effects often peak here Phase Step 4 Weeks Weeks 13-16 Cagrilintide Dose 1.7 mg/week Purpose Approaching maintenance Phase Maintenance Weeks Weeks 17+ Cagrilintide Dose 2.4 mg/week Purpose Target dose used in late-stage study protocols Each step lasts 4 weeks

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Development of novel biosensors to study receptor-mediated activation of the G-protein alpha subunits G(s) and G(olf)