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Yes, most users develop tolerance to semaglutides gastrointestinal side effects over time through physiological adaptation

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Glynnis Page, OMS 2026 Rocky Vista University College of Osteopathic Medicine DOI: 10.70709/r2fykae2uu Abstract Background The use of glucagon-like peptide-1 receptor agonists (GLP-1s) has surged in response to the growing prevalence of type 2 diabetes mellitus and obesitytwo conditions that are known to elevate the risk of perioperative complications in orthopedic surgery