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Immunohistochemical analysis of biopsy and postmortem samples revealed increased expression of UPR markers, including CHOP and BiP, in oligodendrocytes, astrocytes, T cells, and macrophages/microglia within MS lesions

Except for the zinc-binding oxidoreductase with its expression level decreased by 0.3-fold, thioredoxin, heat shock protein 70, glutathione S-transferase, Svf1-like oxidative stress protein, Ish1-like stress-responsive protein, and manganese superoxide dismutase were increased by 0.4-, 0.4-, 0.7-, 0.3-, 0.3-, and 0.3-fold induced by MT treatment, respectively

Pharmacol Res 171:105264

For each 300 L solution, 300 L 50% OptiPrep (diluted in HEPES-KAc buffer) was added