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Approval was based on the results of the KEYNOTE-177 trial (NCT02563002), the most recent in a series of studies focused on the effect of pembrolizumab on solid tumors that led to the 2017 landmark FDA approval of the immune checkpoint inhibitor as a tissue-agnostic treatment in patients with unresectable or metastatic solid tumors demonstrated to be MSI-H or dMMR who have progressed after first-line therapy [117119]

Studying the right cell in acute myelogenous leukemia: dynamic changes of apoptosis and signal transduction pathway protein expression in chemotherapy resistant ex-vivo selected "survivor cells"

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Typical support : approach focused on maintenance and quality of life : rigorous photoprotection, medical camouflage, maintenance nutritional support, psychological support