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Prieto-Hontoria, P., et al., Impact of dietary lipoic acid supplementation on liver mitochondrial bioenergetics and oxidative status on normally fed Wistar rats

A 2024 phase II clinical trial found that although the 12-month DFP treatment successfully reduced the iron content in the hippocampus, it accelerated the cognitive decline of the patients, suggesting that reducing brain iron in such patients may be harmful (143)

Alkaloids are organic compounds with a cyclic ring structure containing one or more basic nitrogen atoms [15] and are often used to treat infectious diseases [16] and antiviral agents [17]

Subsequent analysis using the UK Biobank dataset not only confirmed this finding but also revealed an association between the causal SNP in the GPR146 locus, rs1997243, and C-reactive protein (CRP) levels, as well as plasma liver enzymes, including gamma glutamyl-transferase (GGT), aspartate transaminase (AST), and alkaline phosphatase (ALP) 16,17