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Decreased A clearance and increased amyloid fibril formation associated with apoE4 probably triggers or exacerbates neurodegeneration and the development of AD

Microglial complement receptor 3 can induce ferroptosis via NADPH oxidase 2 (NOX2) (60), and other NADPH oxidases, including NOX1 (61) and NOX4 (62), are also key contributors to the ferroptotic process